Fikes J D, O'Sullivan M G, Bain F T, Jayo M J, Harber E S, Carlson C S
Comparative Medicine Clinical Research Center, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC, USA.
Vet Pathol. 1996 Mar;33(2):171-5. doi: 10.1177/030098589603300206.
Five cases of gastric infarction were observed in adolescent or adult cynomolgus monkeys (Macaca fascicularis) over a 20-month period. Gastric infarcts were encountered as striking and unexpected findings at necropsy. Gross and microscopic findings included gastric necrosis, hemorrhage, and edema that involved large areas of the fundus and pylorus. A consistent finding was the presence of thrombi in the gastric microvasculature, particularly in the venous system. All animals had acute clinical episodes with substantial tissue damage resulting from a variety of causes, including trauma, pancreatitis, necrotizing cystitis, and intestinal intussusception. In addition, three animals had microvascular thrombosis in nongastric tissues. Our findings suggest that cynomolgus monkeys may be predisposed to developing gastric infarction under conditions of severe systemic insult that predispose to disseminated intravascular coagulation.
在20个月的时间里，观察到5例青少年或成年食蟹猴（猕猴）发生胃梗死。胃梗死是在尸检时作为显著且意外的发现而遇到的。大体和显微镜检查结果包括胃坏死、出血和水肿，累及胃底和幽门的大片区域。一个一致的发现是胃微血管中存在血栓，尤其是在静脉系统。所有动物都有急性临床发作，因包括创伤、胰腺炎、坏死性膀胱炎和肠套叠在内的多种原因导致了严重的组织损伤。此外，三只动物在非胃组织中有微血管血栓形成。我们的研究结果表明，食蟹猴在易引发弥散性血管内凝血的严重全身损伤情况下，可能易发生胃梗死。
