Chen H C, Liang C T, Hong C C, Huang Y J, Pan I J
National Laboratory Animal Breeding and Research Center, National Science Council, Taipei, Taiwan (ROC).
Vet Pathol. 1996 Mar;33(2):228-30. doi: 10.1177/030098589603300213.
Naturally occurring squamous cell carcinomas of lung of laboratory rodents are rare, and few cases have been reported and illustrated. A solid peripheral lung mass was observed grossly in a untreated 573-day-old male Sprague Dawley CD (Crl:CD [SD] BR) rat. Microscopically, the mass was composed of neoplastic squamous epithelial cells arranged in nests, cords, nodules, or solid sheets. Epithelial pearls were present. The mitotic index was high, and intercellular bridging (prickles) was noted. In some areas, neoplastic cells rimmed large cystic areas containing neutrophils, cell debris, and laminated keratin masses. Neoplastic cells had both expansive and invasive growth with entrapment of bronchioles and marked fibroplasia.
实验用啮齿动物自然发生的肺鳞状细胞癌很罕见，仅有少数病例被报道及描述。在一只未经处理的573日龄雄性斯普拉格-道利CD（Crl:CD[SD]BR）大鼠中，肉眼观察到肺外周有一个实性肿块。显微镜下，该肿块由呈巢状、索状、结节状或实性片状排列的肿瘤性鳞状上皮细胞组成。可见上皮珠。有丝分裂指数高，并可见细胞间桥（棘突）。在一些区域，肿瘤细胞围绕着大的囊性区域，这些区域含有中性粒细胞、细胞碎片和层状角蛋白团块。肿瘤细胞呈膨胀性和浸润性生长，包绕细支气管并伴有明显的纤维增生。
