Rittinghausen S, Kaspareit J
Fraunhofer Institute of Toxicology and Aerosol Research, Department of Histology, Hannover, Germany.
Toxicol Pathol. 1998 Mar-Apr;26(2):298-300. doi: 10.1177/019262339802600218.
A spontaneous cystic keratinizing epithelioma in the lung of a 704-day-old female Hsd:Sprague-Dawley rat is described. The rat had a white subpleural discoloration on 1 diaphragmatic lobe at necropsy. Microscopically, a central keratin mass, surrounded by a multilayered squamous epithelium of varying thickness, was found. In the periphery of the tumor, epithelial nests projected multifocally into the adjacent alveolar spaces. Immunohistochemical labeling of nuclei by PCNA (proliferating cell nuclear antigen) revealed proliferative activity in 1 or 2 peripheral cell layers in most locations. To the best of the authors' knowledge, this is the first report dealing with the morphological and immunohistochemical features of a spontaneous cystic keratinizing epithelioma in a rat.
本文描述了一只704日龄雌性Hsd:Sprague-Dawley大鼠肺内的自发性囊性角化上皮瘤。尸检时，该大鼠的一个膈叶有白色的胸膜下变色区。显微镜下，发现一个中央角蛋白团块，周围是厚度不一的多层鳞状上皮。在肿瘤周边，上皮巢多处向相邻的肺泡腔突出。用增殖细胞核抗原（PCNA）对细胞核进行免疫组化标记显示，在大多数部位的1或2个外周细胞层中有增殖活性。据作者所知，这是关于大鼠自发性囊性角化上皮瘤的形态学和免疫组化特征的首次报道。
