Rybin E P, Bershtein L M, Tsyrlina E V, Kovalenko I G, Gamaiunova V B, Evtushenko T P, Bokhman I V
Vopr Onkol. 1996;42(3):41-4.
Overweight, lipidemia features, glucose tolerance and insulinemia were studied in 642 females suffering tumors of the corpus uteri, breast, ovary and large bowel, i.e. types of neoplasia which often occur and correspond to the syndrome of primary multiple "hormone-related" cancers. Beside certain obvious similarities in the said parameters established among patients with the said pathologies, the distinctions related, first of all, to degree of pernicious tumor process and, possibly, preoperative weight loss. Since no differences were found in manifestations of hormono-metabolic disturbances between cases of solitary and primary multiple neoplasms of the same localizations, it is suggested that carcinogenesis of both types might be caused by the same factors.
对642名患有子宫体、乳腺、卵巢和大肠肿瘤的女性进行了超重、血脂异常特征、糖耐量和胰岛素血症的研究，这些肿瘤是经常发生的肿瘤类型，与原发性多发性“激素相关”癌症综合征相对应。除了在患有上述疾病的患者中所确定的上述参数存在某些明显相似之处外，这些差异首先与恶性肿瘤进程的程度有关，也可能与术前体重减轻有关。由于在相同部位的孤立性和原发性多发性肿瘤病例之间未发现激素代谢紊乱表现的差异，因此表明这两种类型的致癌作用可能由相同因素引起。
