Rybin E P, Tsyrlina E V, Gamaiunova V B, Vishnevskiĭ A S, Livshits M A, Semiglazov V F, Bershteĭn L M, Bokhman I V
Vopr Onkol. 1996;42(3):45-50.
Blood-serum levels of gonadotrophins and estradiol were assayed alongside with those of estradiol and progesterone receptors in the tissue of tumors of the breast, uterus, ovary and large bowel to establish general regularities of reproductive homeostasis in patients. The study was based on the assumption that risk of secondary tumor development is considerable in a patient who bears one of said malignancies. The effect of estrogen hormones was shown to be one of general causes of tumorigenesis. This is corroborated by enhanced hyperestrinism observed in cases of carcinoma of the corpus uteri as well as by certain data pointing to a reliable correlation between estrogen-stimulated synthesis of progesterone receptors and prognosis in patients with tumors of the breast, uterus and ovary. No estrogen dependence, however, was registered in patients with tumors of the bowel. Pathogenetic features shared by tumors of the large bowel and those of the reproductive system should probably be accounted for by disorders in metabolism.
对乳腺癌、子宫癌、卵巢癌和大肠癌患者肿瘤组织中的促性腺激素、雌二醇水平以及雌二醇和孕激素受体水平进行了检测，以确立患者生殖内稳态的一般规律。该研究基于这样一种假设，即患有上述恶性肿瘤之一的患者发生继发性肿瘤的风险相当高。雌激素激素的作用被证明是肿瘤发生的一般原因之一。子宫内膜癌患者中观察到的高雌激素血症增强以及某些数据表明雌激素刺激的孕激素受体合成与乳腺癌、子宫癌和卵巢癌患者的预后之间存在可靠的相关性，都证实了这一点。然而，在患有肠道肿瘤的患者中未发现雌激素依赖性。大肠癌和生殖系统肿瘤共有的发病机制特征可能是由代谢紊乱引起的。
