Doherty K, Militello F S, Kinnunen T, Garvey A J
School of Dental Medicine, Harvard University, Boston, Massachusetts, USA.
J Consult Clin Psychol. 1996 Aug;64(4):799-807.
The authors examined weight gain in 79 abstinent cigarette smokers during treatment with placebo or with 2 mg or 4 mg of nicotine gum. Results indicated that nicotine gum suppressed weight gain in a linear fashion with increasing nicotine dose. At 90 days postcessation, placebo gum users gained 3.7 kg, 2-mg gum users gained 2.1 kg, and 4-mg gum users gained 1.7 kg. Assessment of nicotine replacement by means of pre- and postcessation salivary continue levels revealed that smokers who replaced a greater percentage of their baseline continue levels during treatment gained less weight. Percentage of baseline cotinine replaced remained related to weight gain after the number of pieces of gum used was controlled. Implications for smokers hoping to minimize postcessation weight gain are discussed.
作者们研究了79名戒烟者在使用安慰剂、2毫克或4毫克尼古丁口香糖治疗期间的体重增加情况。结果表明，尼古丁口香糖随着尼古丁剂量的增加以线性方式抑制体重增加。在戒烟后90天，使用安慰剂口香糖的人增重3.7千克，使用2毫克口香糖的人增重2.1千克，使用4毫克口香糖的人增重1.7千克。通过戒烟前后唾液可替宁水平评估尼古丁替代情况发现，在治疗期间替代其基线可替宁水平百分比更高的吸烟者体重增加较少。在控制了所使用口香糖片数后，替代的基线可替宁百分比仍与体重增加有关。文中讨论了对希望尽量减少戒烟后体重增加的吸烟者的启示。
