Gross J, Stitzer M L, Maldonado J
J Consult Clin Psychol. 1989 Feb;57(1):87-92. doi: 10.1037//0022-006x.57.1.87.
The present study examined nicotine replacement effects on postcessation weight gain in smoking cessation clinic volunteers using objective indices of cigarette smoking, gum use, and body weight. After they achieved abstinence, subjects were randomly assigned to either active nicotine or placebo gum conditions for 10 weeks, during which smoking status was carefully monitored. Analyses revealed strong evidence for a gum effect on weight gain, with active gum users gaining a mean total of 3.8 lb compared with 7.8 lb for placebo gum users at the end of the 10-week trial. Evidence for a dose-response relation was found, suggesting that more gum use (greater than or equal to 6.5 pieces/day) resulted in greater weight suppression. Placebo gum subjects reported greater postcessation increases in eating and hunger compared with active gum subjects. The implications of the weight suppression effect of nicotine gum for smoking cessation treatments are discussed.
本研究使用吸烟、口香糖使用和体重的客观指标，检验了尼古丁替代对戒烟门诊志愿者戒烟后体重增加的影响。在他们实现戒烟后，受试者被随机分配到使用活性尼古丁口香糖或安慰剂口香糖的条件下，为期10周，在此期间仔细监测吸烟状况。分析显示有强有力的证据表明口香糖对体重增加有影响，在10周试验结束时，使用活性口香糖的受试者平均总共增重3.8磅，而使用安慰剂口香糖的受试者增重7.8磅。发现了剂量反应关系的证据，表明更多地使用口香糖（大于或等于6.5片/天）会导致更大程度的体重抑制。与使用活性口香糖的受试者相比，使用安慰剂口香糖的受试者报告称戒烟后进食量和饥饿感增加更多。讨论了尼古丁口香糖的体重抑制作用对戒烟治疗的意义。
