促肾上腺皮质激素/促黑素（4-9）类似物Org 2766对豚鼠内侧前庭核神经元作用的体外研究。
An in vitro investigation of the effects of the ACTH/MSH(4-9) analogue, Org 2766, on guinea pig medial vestibular nucleus neurons.
作者信息
Gilchrist D P, Darlington C L, Smith P F
机构信息
Department of Psychology, University of Otago, New Zealand.
出版信息
Peptides. 1996;17(4):681-8. doi: 10.1016/0196-9781(96)00021-6.
Vestibular compensation is a process of CNS plasticity that is correlated to a return of resting activity in medial vestibular nucleus (MVN) neurons ipsilateral to a peripheral vestibular deafferentation. Systemic administration of melanocortin peptides accelerates the compensation process; the ACTH/MSH(4-9) analogue, Org 2766, accelerates this process at smaller doses than ACTH/MSH(4-10). The present study investigated the effect of Org 2766 on MVN neurons in vitro using extracellular single-cell recording. Org 2766 was less potent at the neuronal level than ACTH/MSH(4-10). When Org 2766 and ACTH/MSH (4-10) were tested consecutively on the same neuron, the response was often different. Org 2766 and ACTH/MSH (4-10) may have a different mode and/or site of action.
前庭代偿是一种中枢神经系统可塑性过程，与外周前庭传入神经切断术同侧的内侧前庭核（MVN）神经元静息活动的恢复相关。全身给予黑皮质素肽可加速代偿过程；促肾上腺皮质激素/促黑素（4-9）类似物Org 2766比促肾上腺皮质激素/促黑素（4-10）以更小的剂量就能加速这一过程。本研究使用细胞外单细胞记录法在体外研究了Org 2766对MVN神经元的作用。Org 2766在神经元水平上的效力低于促肾上腺皮质激素/促黑素（4-10）。当在同一神经元上连续测试Org 2766和促肾上腺皮质激素/促黑素（4-10）时，反应往往不同。Org 2766和促肾上腺皮质激素/促黑素（4-10）可能具有不同的作用方式和/或作用位点。
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