丰加霉素对鼠逆转录病毒70S RNA合成的影响。
Effect of toyocamycin on the synthesis of the 70S RNA of a murine retrovirus.
作者信息
Larsen C J, Mauchauffé M, Hamelin R, Péraudeau L, Fedele L, Tavitian A
出版信息
Nucleic Acids Res. 1979 Apr;6(4):1547-56. doi: 10.1093/nar/6.4.1547.
Abstract
The murine Eveline cell line chronically infected by Friend virus was treated with Toyocamycin (TMC), an adenosin analog and the virions released in the presence of the drug were examined for their RNA. It was found that 70S RNA which was synthesized incorporated Toyocamycin. However, its subunit structure and its poly (A) content were apparently preserved. This incorporation may explain loss of endogenous reverse transcriptase activity.
摘要
用腺苷类似物丰加霉素（TMC）处理长期感染弗氏病毒的小鼠伊芙琳细胞系，检测在该药物存在下释放的病毒粒子的RNA。发现合成的70S RNA掺入了丰加霉素。然而，其亚基结构和聚（A）含量显然得以保留。这种掺入可能解释了内源性逆转录酶活性的丧失。
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