Feng J, Wu G, Tang S, Chahine R, Lamontagne D
Department of Physiology, Faculty of Medicine, Research Center of Sacre-Coeur Hospital, Montreal, Quebec, Canada.
Prostaglandins Leukot Essent Fatty Acids. 1996 Apr;54(4):279-83. doi: 10.1016/s0952-3278(96)90059-9.
To determine whether the prostacyclin analog iloprost plays a beneficial role in crystalloid cardioplegia in isolated working rat hearts, 20 isolated rat hearts were studied after sustaining 90 min of cardioplegic arrest under hypothermia (20 degrees C). The findings indicated that thromboxane A2 (TXA2) levels in coronary effluent were increased during reperfusion. Iloprost (12 nm/l) inhibited the release of TXA2 and improved the recovery of cardiac hemodynamics after ischemia. These data demonstrated that cardiac-derived TXA2 appeared to mediate reperfusion injury after prolonged aortic clamp or cardiac transplantation and iloprost cardioplegic infusion resulted in the inhibition of release of cardiac-derived TXA2 and in a better preservation of cardiac function after ischemic arrest.
为了确定前列环素类似物伊洛前列素在离体工作大鼠心脏的晶体心脏停搏液中是否发挥有益作用，对20个离体大鼠心脏进行了研究，这些心脏在低温（20摄氏度）下经历了90分钟的心脏停搏。研究结果表明，再灌注期间冠状动脉流出液中的血栓素A2（TXA2）水平升高。伊洛前列素（12纳米/升）抑制了TXA2的释放，并改善了缺血后心脏血流动力学的恢复。这些数据表明，心脏源性TXA2似乎介导了长时间主动脉阻断或心脏移植后的再灌注损伤，而伊洛前列素心脏停搏液灌注可抑制心脏源性TXA2的释放，并在缺血性停搏后更好地保存心脏功能。
