Corona R
Servizio di Epidemiologia, Istituto Dermopatico dell'Immacolata, Rome, Italy.
Ann Ist Super Sanita. 1996;32(1):37-42.
The nonmelanoma skin cancers (NMSC), including basal-cell and squamous-cell carcinoma, are the most common type of cancer in white populations. Its incidence has increased has increased worldwide over the last few decades. Mortality from NMSC is low, but the estimated recurrence rate of about 50% at five years and the local invasiveness involve high medical costs and make NMSC a public health concern. Epidemiologic evidence relevant to the effects of UV radiation on the risk of skin cancer comes from both descriptive and analytic studies. More recently, the collaboration between molecular biology and epidemiology has contributed to assess the potential synergism between environmental and genetic factors, such as the capacity of repairing the UV-induced DNA damage, in the etiology of nonmelanoma skin cancer, as by the xeroderma pigmentosum model.
非黑色素瘤皮肤癌（NMSC），包括基底细胞癌和鳞状细胞癌，是白人群体中最常见的癌症类型。在过去几十年里，其发病率在全球范围内呈上升趋势。NMSC的死亡率较低，但据估计，五年的复发率约为50%，且局部侵袭性导致医疗成本高昂，这使得NMSC成为一个公共卫生问题。与紫外线辐射对皮肤癌风险影响相关的流行病学证据来自描述性研究和分析性研究。最近，分子生物学与流行病学之间的合作有助于评估环境因素与遗传因素之间的潜在协同作用，例如在非黑色素瘤皮肤癌病因中修复紫外线诱导的DNA损伤的能力，如通过着色性干皮病模型所示。
