Arici M, Erdem Y, Altun B, Balkanci F, Yasavul U, Turgan C, Cağlar S
Department of Radiology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Am J Kidney Dis. 1996 Sep;28(3):454-6. doi: 10.1016/s0272-6386(96)90506-5.
Acute renal failure caused by radiocontrast agents remains a severe problem, particularly in patients with risk factors. There is debate concerning the pathophysiology of contrast media-induced acute renal failure, including, but not limited to, renal ischemia or tubular damage. Vascular ischemia is considered a major contributor because consistent changes in renal hemodynamics have been recorded experimentally. We describe a patient who has a typical course of contrast-associated renal failure manifested by severe renal vasoconstriction and backflow of the contrast agent during renal angiography performed after 6 days of an intravenous urography. Such degree of renal vasoconstriction is noteworthy in that this particular case might serve as a model in delineation of the pathogenetic mechanisms of acute renal failure after contrast media administration.
由放射性造影剂引起的急性肾衰竭仍然是一个严重问题，尤其是在有危险因素的患者中。关于造影剂诱导的急性肾衰竭的病理生理学存在争议，包括但不限于肾缺血或肾小管损伤。血管缺血被认为是主要原因，因为实验中已记录到肾血流动力学的持续变化。我们描述了一名患者，其在静脉肾盂造影6天后进行肾血管造影时，出现了典型的造影剂相关性肾衰竭过程，表现为严重的肾血管收缩和造影剂逆流。这种程度的肾血管收缩值得注意，因为这个特殊病例可能作为一个模型来描绘造影剂给药后急性肾衰竭的发病机制。
