Cueva-Rolón R, Sansone G, Bianca R, Gómez L E, Beyer C, Whipple B, Komisaruk B R
Center for Research in Animal Reproduction (CIRA), Centro de Investigación y Estudios Avanzados, Unidad Tlaxcala, México.
Physiol Behav. 1996 Jul;60(1):19-24. doi: 10.1016/0031-9384(95)02245-7.
To ascertain whether any effects of vaginocervical stimulation (VS) are mediated by the vagus nerve, all known afferent nerves from the reproductive tract to the spinal cord were transected and the rats were tested for residual responses to VS. After combined bilateral transection of the pelvic, hypogastric, and pudendal nerves (NX), the following responses to VS were greatly reduced or abolished: lordosis to flank-perineum palpation, leg extension, immobilization, and blockage of both tail withdrawal to radiant heat and leg withdrawal to foot pinch. However, after these nerve cuts, the following persisted as significant residual responses to VS: 1) analgesia [measured as increase in vocalization threshold (VOCT) to tailshock], 2) pupil dilatation (PD), and 3) increase in heart rate (HR). Subsequent bilateral subdiaphragmatic vagotomy (VX) significantly reduced the magnitude of PD and abolished the analgesia. By contrast, VX produced no significant effect on the HR increase to VS. The above findings provide evidence that brain-mediated responses to vaginocervical stimulation can be elicited via the vagus nerves.
为了确定阴道宫颈刺激（VS）的任何效应是否由迷走神经介导，切断了所有已知的从生殖道到脊髓的传入神经，并对大鼠进行VS残余反应测试。在双侧切断盆腔神经、腹下神经和阴部神经（NX）后，对VS的以下反应大大降低或消失：对胁腹 - 会阴触诊的脊柱前凸、腿部伸展、固定以及对辐射热尾巴退缩和对足部夹捏腿部退缩的阻断。然而，在这些神经切断后，以下反应作为对VS的显著残余反应仍然存在：1）镇痛[以对尾部电击的发声阈值（VOCT）增加来衡量]，2）瞳孔扩张（PD），以及3）心率增加（HR）。随后的双侧膈下迷走神经切断术（VX）显著降低了PD的幅度并消除了镇痛作用。相比之下，VX对VS引起的HR增加没有显著影响。上述发现提供了证据，表明对阴道宫颈刺激的脑介导反应可通过迷走神经引发。
