Gómez L E, Ortega C, Durán I, Cueva-Rolón R
Centro de Investigación en Reproducción Animal, CINVESTAV, Tlaxcala, Mexico.
J Auton Nerv Syst. 1996 Sep 12;60(3):154-62. doi: 10.1016/0165-1838(96)00048-3.
The rise in blood pressure and heart rate produced by the mechanical stimulation of the uterine cervix (VS) was examined after adrenalectomy, after pelvic or hypogastric neurectomies or after spinal cord transection in anesthetized rats. Neither adrenalectomy, nor hypogastric neurectomy prevented the rise in heart rate and blood pressure produced by VS. After the spinal cord transection at T6 level, VS was still able to produce the rise in blood pressure. However, the rise in blood pressure was significantly lower than that produced in the same animals before the transection. No changes in heart rate were produced by VS after spinal cord transection. This result can be explained because this level of transection prevents the reach of the afferent inflow to the superior cervical ganglia. Pelvic neurectomy abolished completely the effects of VS on blood pressure and heart rate. Low intensity (1-2 times the threshold) electrical stimulation of the pelvic nerve produced a rise in blood pressure. Even though heart rate increased during electrical stimulation, the change in heart rate was not statistically different from the pre-stimulation value. These results suggest that the changes in blood pressure and heart rate produced by VS represent a neuronal reflex response mediated by the pelvic nerve. The fact that the effects of VS on blood pressure persist in spinal cord-transected animals suggests that the reflex is integrated at the spinal level. However, the cardiovascular responses to VS were significantly lower than before transection, suggesting that supraspinal centers are also involved in the reflex.
在麻醉大鼠中，分别于肾上腺切除术后、盆腔或腹下神经切除术后或脊髓横断术后，检测子宫颈机械刺激（VS）所引起的血压和心率升高情况。肾上腺切除术和腹下神经切除术均不能阻止VS所引起的心率和血压升高。在T6水平脊髓横断后，VS仍能引起血压升高。然而，此时血压升高幅度明显低于横断前同一动物的升高幅度。脊髓横断后，VS未引起心率变化。这一结果可以解释为，该横断水平阻止了传入神经冲动到达颈上神经节。盆腔神经切除术完全消除了VS对血压和心率的影响。低强度（阈值的1 - 2倍）电刺激盆腔神经可引起血压升高。尽管电刺激期间心率增加，但心率变化与刺激前值相比无统计学差异。这些结果表明，VS所引起的血压和心率变化代表了由盆腔神经介导的神经元反射反应。VS对血压的影响在脊髓横断动物中仍然存在，这一事实表明该反射在脊髓水平整合。然而，对VS的心血管反应明显低于横断前，表明脊髓以上中枢也参与了该反射。
