脑室内注射胆囊收缩素可降低猪的操作性食糖摄入量。

Intracerebroventricular injection of CCK reduces operant sugar intake in pigs.

作者信息

Baldwin B A, Sukhchai S

机构信息

Department of Neurobiology, Babraham Institute, Cambridge, UK.

出版信息

Physiol Behav. 1996 Jul;60(1):231-3. doi: 10.1016/0031-9384(95)02211-2.

DOI:10.1016/0031-9384(95)02211-2

PMID:8804668

Abstract

Pigs have a strong appetite for sugar solutions and readily learn to perform operant responses (pressing a panel with their snouts) to obtain glucose solution. Intracerebroventricular (ICV) injection of 1 microgram CCK produced a significant (p < 0.01) reduction in the amount of glucose consumed compared with saline in the 30 min following injection. The reduction was a central effect as the same dose of CCK was ineffective given intravenously. The inhibition of intake was completely abolished by prior dosing with 100 micrograms of the CCKA receptor antagonist Devazepide given ICV. Devazepide itself had no effect on intake. The pig is a good experimental animal for the study of the regulation of sugar intake.

摘要

猪对糖溶液有强烈的食欲，并且很容易学会通过操作性反应（用鼻子按压面板）来获取葡萄糖溶液。脑室内（ICV）注射1微克胆囊收缩素（CCK）后，与注射生理盐水相比，在注射后的30分钟内，葡萄糖摄入量显著减少（p < 0.01）。这种减少是一种中枢效应，因为相同剂量的CCK静脉注射无效。预先脑室内注射100微克CCKA受体拮抗剂德伐西匹可完全消除对摄入量的抑制作用。德伐西匹本身对摄入量没有影响。猪是研究糖摄入调节的良好实验动物。