年轻人和老年人的唾液免疫球蛋白A分泌率。

Salivary IgA secretion rate in young and elderly persons.

作者信息

Miletic I D, Schiffman S S, Miletic V D, Sattely-Miller E A

机构信息

Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA.

出版信息

Physiol Behav. 1996 Jul;60(1):243-8. doi: 10.1016/0031-9384(95)02161-2.

DOI:10.1016/0031-9384(95)02161-2

PMID:8804670

Abstract

Immunoglobulin A (IgA) is the dominant immunoglobulin isotype on all mucosal surfaces where it acts as a first line of defense against microbial invasion. Recent investigations suggest that secretory IgA (sIgA) concentrations vary over the day due to a range of variables including dietary factors, daily mood, and exercise. In this study, salivary IgA was determined by ELISA in samples of 48 persons grouped as "young" (20-30 years old) and "elderly" (60-80 years old). Unstimulated, stabilized morning and afternoon saliva was collected during 7 consecutive days. Saliva flow, total proteins, sIgA concentrations, and sIgA secretion rates were determined. The main finding was that saliva flow and sIgA secretion rate were significantly lower in the elderly than in the young. Salivary IgA secretion rate was found to be independent of total proteins secreted in all samples. There is individual variability within a particular age group. It was also found that stress and daily events influence the sIgA secretion rate.

摘要

免疫球蛋白A（IgA）是所有黏膜表面占主导地位的免疫球蛋白同种型，在这些黏膜表面它作为抵御微生物入侵的第一道防线。最近的研究表明，由于包括饮食因素、日常情绪和运动等一系列变量，分泌型IgA（sIgA）的浓度在一天中会有所变化。在本研究中，通过酶联免疫吸附测定法（ELISA）对48名被分为“年轻人”（20至30岁）和“老年人”（60至80岁）的受试者样本中的唾液IgA进行了测定。在连续7天内收集未刺激的、稳定的早晨和下午唾液。测定了唾液流速、总蛋白、sIgA浓度和sIgA分泌率。主要发现是老年人的唾液流速和sIgA分泌率显著低于年轻人。发现在所有样本中唾液IgA分泌率与分泌的总蛋白无关。在特定年龄组内存在个体差异。还发现压力和日常事件会影响sIgA分泌率。