Henderson J, Greene E
Brain Res Bull. 1977 Mar-Apr;2(2):123-9. doi: 10.1016/0361-9230(77)90008-9.
Lesions which sever different parts of precommissural or postcommissural fornix were compared to the effects of control lesions in several behavioral tasks. Spatial learning and avoidance was impaired by lesions of the descending columns, or by lesions which sever the precommissural communications passing to and from medial septum. Damage to precommissural fibers through lateral septum produced a measurable change only on the avoidance task. This pattern of deficits, considered together with the anatomical relationship of the system, suggests a model in which the medial septum relays kinesthetic information to dorsal hippocampus, which in turn serves as a memory system in the performance of spatial habits. It is less clear what kind of information is relayed by lateral septum, but it may communicate with ventral hippocampus regarding the consequences of punishment, and thus serve as part of a system for defensive suppression of behavior.
将切断连合前或连合后穹窿不同部分的损伤与对照损伤在若干行为任务中的效应进行了比较。下行柱的损伤，或切断与内侧隔往返的连合前联系的损伤，会损害空间学习和回避能力。通过外侧隔对连合前纤维的损伤仅在回避任务上产生了可测量的变化。这种缺陷模式，结合该系统的解剖关系来看，提示了一种模型，即内侧隔将动觉信息传递给背侧海马体，而背侧海马体反过来在空间习惯的执行中充当记忆系统。外侧隔传递何种信息尚不清楚，但它可能就惩罚的后果与腹侧海马体进行交流，从而作为行为防御抑制系统的一部分发挥作用。
