Davis R E, Kent E W
J Comp Physiol Psychol. 1979 Dec;93(6):1182-92. doi: 10.1037/h0077633.
This investigation demonstrates the importance of the direct hippocampo-anterior thalamic component of the postcommissural fornix in the control of general locomotion and active avoidance. Transection of anterior thalamic afferents from the hippocampal formation (subicular cortex), at the point where they exit from the fornix posterior to the septum, is sufficient to enhance bidirectional active avoidance acquisition and increase general activity. This transection may also interrupt fibers to or from other thalamic nuclei and the anterior septum. However, destruction of connections of the anterior septum with the hippocampus, habenula, and thalamus by transection in the coronal plane anterior to the descending fornix columns, without damage to the subiculothalamic fibers, increases general activity levels without damage to the subiculothalamic fibers, increases general activity levels without affecting active avoidance behavior. The activity increase in this case resembles that seen after septal lesions rather than that seen after hippocampal lesions. Thus, destruction of a single fornix component contributing afferents to the anterior thalamic nuclei reproduces at least part of the hippocampal syndrome. This suggests that these fibers contribute significantly to the control of these behaviors and may mediate active avoidance changes resulting from hippocampal and fornix damage.
本研究证明了连合后穹窿的直接海马-丘脑前成分在控制一般运动和主动回避中的重要性。在海马结构（下托皮质）发出的丘脑前传入纤维从穹窿穿出至隔后处进行横切，足以增强双向主动回避的习得并增加一般活动。这种横切也可能中断与其他丘脑核团和前隔的纤维联系。然而，在穹窿柱下降之前的冠状平面进行横切，破坏前隔与海马、缰核和丘脑的连接，而不损伤下托-丘脑纤维，可增加一般活动水平且不影响主动回避行为。这种情况下的活动增加类似于隔损伤后所见，而非海马损伤后所见。因此，破坏单个向丘脑前核传入纤维的穹窿成分至少再现了部分海马综合征。这表明这些纤维对这些行为的控制有显著贡献，并可能介导由海马和穹窿损伤导致的主动回避变化。
