Val-Bernal J F, Garijo M F
Anatomical Pathology Department, Marqués de Valdecilla University Hospital, Medical Faculty, University of Cantabria, Santander, Spain.
Am J Dermatopathol. 1996 Jun;18(3):317-21. doi: 10.1097/00000372-199606000-00014.
In the present report, we describe a cutaneous myofibroma with a monophasic pattern. The patient was a 12-year-old white boy with an asymptomatic yellow nodule on his glans penis for about 2 1/2 months. The nodular pattern of growth is distinctive: nests of plump spindle cells with a tendency toward interstitial hyalinization within the dermis. Confirmation of the myofibroblastic nature of the proliferation was obtained by histochemical and immunohistochemical studies. The tumor cells showed immunoreactivities for vimentin, alpha-smooth-muscle actin, and collagen type IV but did not stain for desmin. To the best of our knowledge, this is the first case of cutaneous myofibroma to occur on the glans penis. This tumor should be included in the differential diagnosis of mesenchymal neoplasms of the penis.
在本报告中，我们描述了一例具有单相模式的皮肤肌纤维瘤。患者为一名12岁白人男孩，其阴茎头出现一个无症状黄色结节约2个半月。结节状生长模式独特：真皮内有丰满的梭形细胞巢，有间质透明化倾向。通过组织化学和免疫组织化学研究证实了增殖的肌成纤维细胞性质。肿瘤细胞对波形蛋白、α-平滑肌肌动蛋白和IV型胶原呈免疫反应，但对结蛋白不染色。据我们所知，这是首例发生于阴茎头的皮肤肌纤维瘤。该肿瘤应纳入阴茎间叶性肿瘤的鉴别诊断。
