Sugatani T, Inui M, Tagawa T, Seki Y, Mori A, Yoneda J
Department of Oral and Maxillofacial Surgery, Mie University Japan.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Sep;80(3):303-9. doi: 10.1016/s1079-2104(05)80388-9.
A case of mandibular myofibroma in a 2-month-old boy is presented. Including this case, 24 pediatric and 11 adult patients with maxillofacial myofibroma have been reported since 1981. Of the 24 pediatric patients, 15 (62.5%) had lesions affecting the mandible. The adult cases had no mandibular involvement. Histologic evaluation of the tissue specimen revealed an interlacing pattern of spindle-shaped cells with long oval nuclei. Tissue immunohistochemical staining found it to be reactive for antibodies directed against vimentin and alpha-smooth muscle actin, but not desmin, S-100 protein, neuron-specific enolase, or myoglobin. Electron microscopy examination revealed the following cells: myofibroblast-like cells, fibroblast-like cells, and intermediate cells that were similar to the fibroblast-like cells except for the presence of a few microfilaments. Myoblast-like cells were not seen.
本文报告了一例2个月大男婴的下颌骨肌纤维瘤病例。自1981年以来，包括本病例在内，共报告了24例儿童和11例成人颌面部肌纤维瘤患者。在24例儿童患者中，15例（62.5%）病变累及下颌骨。成人病例未累及下颌骨。组织标本的组织学评估显示，梭形细胞呈交错排列，细胞核呈长椭圆形。组织免疫组化染色发现，其对波形蛋白和α-平滑肌肌动蛋白抗体呈阳性反应，但对结蛋白、S-100蛋白、神经元特异性烯醇化酶或肌红蛋白抗体无反应。电子显微镜检查发现了以下几种细胞：肌成纤维细胞样细胞、成纤维细胞样细胞以及除了存在一些微丝外与成纤维细胞样细胞相似的中间细胞。未发现成肌细胞样细胞。
