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1
Heterocyclic amines: evaluation of their role in diet associated human cancer.杂环胺：评估它们在与饮食相关的人类癌症中的作用。
Br J Clin Pharmacol. 1996 Jul;42(1):91-8. doi: 10.1046/j.1365-2125.1996.37513.x.
2
Assessing human risk to heterocyclic amines.评估杂环胺对人类的风险。
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Intra- and interindividual variability in systemic exposure in humans to 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline and 2-amino-1-methyl- 6-phenylimidazo[4,5-b]pyridine, carcinogens present in cooked beef.人体对2-氨基-3,8-二甲基咪唑并[4,5-f]喹喔啉和2-氨基-1-甲基-6-苯基咪唑并[4,5-b]吡啶（熟牛肉中存在的致癌物）的全身暴露在个体内和个体间的变异性。
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4
Mutagenic activation of IQ, PhIP and MeIQx by hepatic microsomes from rat, monkey and man: low mutagenic activation of MeIQx in cynomolgus monkeys in vitro reflects low DNA adduct levels in vivo.大鼠、猴和人肝脏微粒体对IQ、PhIP和MeIQx的诱变激活作用：食蟹猴体外实验中MeIQx的低诱变激活反映其体内低DNA加合物水平。
Carcinogenesis. 1993 Jan;14(1):61-5. doi: 10.1093/carcin/14.1.61.
5
Contribution of CYP1A1 and CYP1A2 to the activation of heterocyclic amines in monkeys and human.CYP1A1和CYP1A2在猴子和人类中对杂环胺激活的作用。
Carcinogenesis. 1994 May;15(5):829-36. doi: 10.1093/carcin/15.5.829.
6
Activation and effects of the food-derived heterocyclic amines in extrahepatic tissues.食物来源的杂环胺在肝外组织中的激活及其作用。
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Effect of cruciferous vegetable consumption on heterocyclic aromatic amine metabolism in man.食用十字花科蔬菜对人体杂环胺代谢的影响。
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8
Pan-fried meat containing high levels of heterocyclic aromatic amines but low levels of polycyclic aromatic hydrocarbons induces cytochrome P4501A2 activity in humans.含有高水平杂环芳香胺但低水平多环芳烃的煎肉会诱导人体细胞色素P4501A2活性。
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Systemic exposure to dietary heterocyclic amines in man.
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Possible relationship between tissue distribution of DNA adducts and genotoxicity of food-derived heterocyclic amines.DNA加合物的组织分布与食物来源的杂环胺的遗传毒性之间的可能关系。
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Using 3D MCF-7 mammary spheroids to assess the genotoxicity of mixtures of the food-derived carcinogens benzo[]pyrene and 2-amino-1-methyl-6-phenylimidazo[4,5-]pyridine.使用3D MCF-7乳腺球状体评估食品源性致癌物苯并[a]芘和2-氨基-1-甲基-6-苯基咪唑[4,5-b]吡啶混合物的遗传毒性。
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Ethanol potentiates the genotoxicity of the food-derived mammary carcinogen PhIP in human estrogen receptor-positive mammary cells: mechanistic support for lifestyle factors (cooked red meat and ethanol) associated with mammary cancer.乙醇增强了食物来源的致乳腺癌物 PhIP 在人雌激素受体阳性乳腺细胞中的遗传毒性：与乳腺癌相关的生活方式因素（熟红肉和乙醇）的机制支持。
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Mutagenic nucleotide incorporation and hindered translocation by a food carcinogen C8-dG adduct in Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4): modeling and dynamics studies.嗜热栖热菌P2 DNA聚合酶IV（Dpo4）中食物致癌物C8-dG加合物导致的诱变核苷酸掺入和易位受阻：建模与动力学研究
Nucleic Acids Res. 2006 Jul 4;34(11):3326-37. doi: 10.1093/nar/gkl425. Print 2006.
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Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism.结直肠癌患者和对照组细胞色素P450 CYP1A2基因（CYP1A2）的多态性：等位基因频率、连锁不平衡及对咖啡因代谢的影响。
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6
Solution structure of the 2-amino-1- methyl-6-phenylimidazo[4,5-b]pyridine C8-deoxyguanosine adduct in duplex DNA.双链DNA中2-氨基-1-甲基-6-苯基咪唑并[4,5-b]吡啶C8-脱氧鸟苷加合物的溶液结构
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7
Functional significance of a C-->A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine.利用咖啡因检测细胞色素P450 CYP1A2基因内含子1中C→A多态性的功能意义。
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Expression of arylamine N-acetyltransferase in human intestine.芳基胺N-乙酰基转移酶在人体肠道中的表达。
Gut. 1998 Mar;42(3):402-9. doi: 10.1136/gut.42.3.402.

杂环胺：评估它们在与饮食相关的人类癌症中的作用。

Heterocyclic amines: evaluation of their role in diet associated human cancer.

作者信息

Gooderham N J, Murray S, Lynch A M, Edwards R J, Yadollahi-Farsani M, Bratt C, Rich K J, Zhao K, Murray B P, Bhadresa S, Crosbie S J, Boobis A R, Davies D S

机构信息

Department of Clinical Pharmacology, Royal Postgraduate Medical School, London, UK.

出版信息

Br J Clin Pharmacol. 1996 Jul;42(1):91-8. doi: 10.1046/j.1365-2125.1996.37513.x.

DOI:10.1046/j.1365-2125.1996.37513.x
PMID:8807149
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2042638/
Abstract
  1. Heterocyclic amines are formed in parts per billion levels when meat is cooked. 2. The heterocyclic amines MeIQx and PhIP are efficiently absorbed into the systemic circulation after ingestion of cooked food. 3. We have shown that MeIQx and PhIP, both in vitro and in vivo, are substrates for human hepatic CYP1A2, which exclusively and efficiently catalyses their conversion to genotoxic hydroxylamines. 4. MeIQx and PhIP are promutagens. MeIQx is a very powerful bacterial mutagen whereas PhIP is a more potent mammalian cell mutagen. Using a mammalian cell target gene, hprt, we have shown that PhIP induces a characteristic mutational 'fingerprint'. 5. MeIQx and PhIP are carcinogenic in bioassays. The PhIP mutational 'fingerprint' has been detected in the Apc gene of 5/8 colonic tumours induced by PhIP in rats.
摘要
  1. 肉类烹饪时会形成十亿分之几水平的杂环胺。2. 摄入熟食后，杂环胺MeIQx和PhIP能有效吸收进入体循环。3. 我们已表明，无论是在体外还是体内，MeIQx和PhIP都是人肝脏CYP1A2的底物，CYP1A2专门且有效地催化它们转化为具有基因毒性的羟胺。4. MeIQx和PhIP是前诱变剂。MeIQx是一种非常强大的细菌诱变剂，而PhIP是一种更有效的哺乳动物细胞诱变剂。使用哺乳动物细胞靶基因hprt，我们已表明PhIP会诱导出特征性的突变“指纹”。5. MeIQx和PhIP在生物测定中具有致癌性。在大鼠中由PhIP诱导的5/8结肠肿瘤的Apc基因中检测到了PhIP突变“指纹”。