Commentz J C, Helmke K
Department of Pediatrics UKE, University of Hamburg, Germany.
Horm Res. 1995;44(6):271-5. doi: 10.1159/000184640.
Hypothalamic hamartomata are benign malformations of the brain consisting of heterotopic nervous tissue, and are often associated with precocious puberty and gelastic seizures in early childhood. We report for the first time the melatonin plasma values of a girl with central precocious puberty and gelastic seizures due to a hypothalamic hamartoma. The melatonin plasma levels were low for the chronological age but appropriate for the pubertal status, making a causal relationship between lowered melatonin plasma levels and precocious puberty possible.
下丘脑错构瘤是由异位神经组织构成的脑部良性畸形，常与儿童早期的性早熟和痴笑性癫痫相关。我们首次报告了一名因下丘脑错构瘤导致中枢性性早熟和痴笑性癫痫的女孩的血浆褪黑素值。按实际年龄计算，其血浆褪黑素水平较低，但与青春期状态相符，这使得血浆褪黑素水平降低与性早熟之间可能存在因果关系。
