Liu Y, Dehni G, Purcell K J, Sokolow J, Carcangiu M L, Artavanis-Tsakonas S, Stifani S
Montreal Neurological Institute, McGill University, Quebec, Canada.
Genomics. 1996 Jan 1;31(1):58-64. doi: 10.1006/geno.1996.0009.
The TLE genes are the human homologues of Drosophila groucho, a member of the Notch signaling pathway. This pathway controls a number of different cell-fate choices in invertebrates and vertebrates. We are interested in investigating the functions of the TLE gene family during epithelial determination and carcinogenesis. We show that expression of individual TLE genes correlates with immature epithelial cells that are progressing toward their terminally differentiated state, suggesting a role during epithelial differentiation. In both normal tissues and conditions resulting from incorrect or incomplete maturation events, such as metaplastic and neoplastic transformations, TLE expression is elevated and coincides with Notch expression, implicating these molecules in the maintenance of the undifferentiated state in epithelial cells. We also show that TLE1 and TLE2 are organized in a tandem array at chromosomal location 19p13.3, while TLE3 maps to 15q22.
TLE基因是果蝇gro基因在人类中的同源基因，gro基因是Notch信号通路的成员之一。该信号通路控制着无脊椎动物和脊椎动物中许多不同的细胞命运选择。我们感兴趣的是研究TLE基因家族在上皮细胞决定和致癌过程中的功能。我们发现，单个TLE基因的表达与正在向终末分化状态发展的未成熟上皮细胞相关，提示其在上皮细胞分化过程中发挥作用。在正常组织以及由不正确或不完全成熟事件导致的情况中，如化生和肿瘤转化，TLE表达升高且与Notch表达一致，这表明这些分子参与维持上皮细胞的未分化状态。我们还发现，TLE1和TLE2在染色体19p13.3位点呈串联排列，而TLE3定位于15q22。
