Severini G, Diana L, Di Giovannandrea R, Sagliaschi G
Laboratorio di Biochimica Clinica, Istituto Superiore di Sanità, Roma, Italia.
ASAIO J. 1996 Jan-Feb;42(1):64-7.
The influence of uremic middle molecules on in vitro lymphocyte blast transformation and interleukin-2 production was studied in 12 patients on long-term hemodialysis and 12 healthy control subjects with normal kidney function. Middle molecules inhibit phytohemoagglutinin induced lymphocyte proliferation in a concentration dependent fashion, achieving more than 50% inhibition of tritiated thymidine incorporation after 72 hrs in culture. In addition, there was less interleukin-2 production in the long-term hemodialysis patients studied compared with healthy control subjects.
对12例长期接受血液透析的患者及12名肾功能正常的健康对照者，研究了尿毒症中分子物质对体外淋巴细胞转化及白细胞介素-2产生的影响。中分子物质以浓度依赖方式抑制植物血凝素诱导的淋巴细胞增殖，培养72小时后对氚标记胸腺嘧啶核苷掺入的抑制率超过50%。此外，与健康对照者相比，所研究的长期血液透析患者产生的白细胞介素-2较少。
