Simonart T h, Parent D, Heenen M, Farber C M, Van Vooren J P
Department of Dermatology, Erasme Hospital, University Hospital, Brussels, Belgium.
Clin Immunol Immunopathol. 1996 Oct;81(1):12-5. doi: 10.1006/clin.1996.0150.
To evaluate the skin reactivity and the mast cell releasibility in the acquired immunodeficiency syndrome (AIDS), 24 patients with AIDS were skin tested with histamine (1 mg/ml) and codeine phosphate (0.9, 0.09, and 0.009 mg/ml), a mast cell degranulating agent. They were compared to 12 HIV-negative healthy volunteers and 16 urticaria-prone subjects. Reactivity to codeine phosphate was lower in patients with AIDS than in HIV-negative subjects. This difference in skin reactivity was the more significant when the AIDS group was compared to the urticaria-prone group. There was no correlation between the reactivity to codeine and the IgE levels. Possible explanations to the decreased skin reacting to codeine in patients with AIDS include a decrease of local mast cell density or releasibility. This suggests that a mechanism related to urticaria and involving mast cells is quite unlikely to be at the origin of the hypersensitivity reactions observed in AIDS.
为评估获得性免疫缺陷综合征（艾滋病）患者的皮肤反应性和肥大细胞释放能力，对24例艾滋病患者用组胺（1毫克/毫升）和磷酸可待因（0.9、0.09和0.009毫克/毫升）（一种肥大细胞脱颗粒剂）进行皮肤试验。将他们与12名HIV阴性健康志愿者和16名易患荨麻疹的受试者进行比较。艾滋病患者对磷酸可待因的反应性低于HIV阴性受试者。当将艾滋病组与易患荨麻疹组进行比较时，这种皮肤反应性差异更为显著。对可待因的反应性与IgE水平之间无相关性。艾滋病患者对可待因皮肤反应降低的可能解释包括局部肥大细胞密度或释放能力降低。这表明与荨麻疹相关且涉及肥大细胞的机制不太可能是艾滋病中观察到的超敏反应的起源。
