Voss A C, Seeliger H C
Strahlentherapie. 1979 Apr;155(4):230-6.
Conclusions are drawn for irradiation planning from treatment results of 161 patients with inoperable esophageal carcinomas, comparable with reference to the technique applied using moving-field irradiation and delivering a total focal dose of 6000 rd. The palliative effect of radiation therapy is obtained by measurable dilatation of the stenosis in more than 90% of the patients. 5-year survival, however, was found only in cases of an average target volume comprising 500 cm3 within the 80% isodose, largely independent of the stage of the primary tumor. The best correlation between tumor extension and target volume is found in T3 tumors. A target volume larger than 700 cm3 does not seem to be required. The rate and localization of the recurrences are showing that a minimum safety distance beyond the radiologically ascertained tumor expansion is indispensable.
根据161例无法手术的食管癌患者的治疗结果得出放射治疗计划的结论，这些患者在应用移动野照射技术和给予6000拉德总焦点剂量方面具有可比性。放射治疗的姑息效果通过超过90%的患者狭窄部位可测量的扩张获得。然而，5年生存率仅在80%等剂量线内平均靶体积为500立方厘米的病例中发现，很大程度上与原发肿瘤的分期无关。在T3肿瘤中发现肿瘤扩展与靶体积之间的最佳相关性。似乎不需要大于700立方厘米的靶体积。复发的发生率和部位表明，在放射学确定的肿瘤扩展范围之外有一个最小安全距离是必不可少的。
