Wannenmacher M, Slanina J, Bruggmoser G, Nanko N
Radiologe. 1986 Oct;26(10):479-89.
From 1965-1985, in the Department of Radiotherapy of the University Hospital of Freiburg 226 patients with esophageal carcinoma have been treated with primary radiotherapy at a sufficient tumor dose - 138 of them with curative and 66 patients with palliative intention. With curative irradiation the survival rates between 1 at 5 years were 28.6%, 14.1%, 8.2%, 5.8% and 3.5%. To palliative indication the 1 year survival rate was 10.4%, none of these patients reached the two years' limit. Apparently relevant prognostic factors are: length of history, overall state of health, histologic classification, tumor stage, state of clinical remission, localization of the tumor. Our findings were compared with observations between 1965 and 1985. This paper deals with the problems of pre- and post-therapeutic irradiation, in combination with chemotherapy. Indications for radiotherapy, definition of the target volume and the different techniques of radiation planning and performance are discussed, especially with reference to comparison of stimulator- and CT-assisted radiation planning. We demonstrate the possibilities of rotation therapy with an electronically controlled diaphragm device developed in our department.
1965年至1985年期间，弗莱堡大学医院放射治疗科对226例食管癌患者进行了原发灶放疗，给予足够的肿瘤剂量，其中138例为根治性放疗，66例为姑息性放疗。根治性放疗患者的1年、5年生存率分别为28.6%、14.1%、8.2%、5.8%和3.5%。姑息性放疗患者的1年生存率为10.4%，无一例存活超过两年。明显相关的预后因素有：病程长短、总体健康状况、组织学分类、肿瘤分期、临床缓解状态、肿瘤部位。我们将研究结果与1965年至1985年期间的观察结果进行了比较。本文探讨了放疗前后联合化疗的问题。讨论了放疗适应证、靶区定义以及不同的放疗计划制定和实施技术，特别是对比了模拟定位机辅助和CT辅助放疗计划。我们展示了使用我们科室研发的电子控制光阑装置进行旋转治疗的可能性。
