Hirano T, Yamaguchi R, Asami S, Iwamoto N, Kasai H
Department of Environmental Oncology, University of Occupational and Environmental Health, Kitakyushu, Japan.
J Gerontol A Biol Sci Med Sci. 1996 Sep;51(5):B303-7. doi: 10.1093/gerona/51a.5.b303.
8-Hydroxyguanine (8-OH-Gua) is one of the most abundant types of oxidative DNA damage. The levels of 8-OH-Gua, and its repair activity, were quantified in 3-week-, 5-month-, and 30-month-old male Sprague-Dawley rat organs such as liver, kidney, spleen, lung, small intestine, and brain. The levels of 8-OH-Gua were significantly higher in the 5-month-old rat kidney and brain and 30-month-old rat spleen when compared to that of the 3-week-old rats. However, no significant differences were found in the organs between 5- and 30-month-old rats that were due to the aging process. The repair activity levels of kidney, spleen, and lung were higher than those of liver, small intestine, and brain. This pattern was consistent for the three age stages.
8-羟基鸟嘌呤（8-OH-Gua）是氧化性DNA损伤中最常见的类型之一。对3周龄、5月龄和30月龄雄性斯普拉格-道利大鼠的肝脏、肾脏、脾脏、肺、小肠和大脑等器官中的8-OH-Gua水平及其修复活性进行了定量分析。与3周龄大鼠相比，5月龄大鼠的肾脏和大脑以及30月龄大鼠的脾脏中8-OH-Gua水平显著更高。然而，5月龄和30月龄大鼠的器官之间未发现因衰老过程导致的显著差异。肾脏、脾脏和肺的修复活性水平高于肝脏、小肠和大脑。这种模式在三个年龄阶段都是一致的。
