Ihn H, Sato S, Fujimoto M, Kikuchi K, Igarashi A, Soma Y, Tamaki K, Takehara K
Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan.
Clin Exp Immunol. 1996 Sep;105(3):475-9. doi: 10.1046/j.1365-2249.1996.d01-774.x.
In order to determine the prevalence and clinical significance of beta 2-GPI-dependent anticardiolipin antibodies (beta 2-GPI/aCL) in patients with systemic sclerosis (SSc), serum samples from 80 patients with SSc, 20 patients with systemic lupus erythematosus (SLE), and 120 healthy control subjects were examined by ELISA using purified beta 2-GPI. IgG isotype beta 2-GPI/aCL was present in eight of 80 patients with SSc (10%), and the presence of beta 2-GPI/aCL IgG was significantly correlated with the presence of isolated pulmonary hypertension (PH). Furthermore, levels of beta 2-GPI/aCL IgG were significantly correlated with levels of mean pulmonary arterial pressure. These data suggest that IgG isotype beta 2-GPI/aCL might be a serological indicator of the severity of PH in patients with SSc.
为了确定β2-糖蛋白I依赖性抗心磷脂抗体（β2-GPI/aCL）在系统性硬化症（SSc）患者中的患病率及其临床意义，我们使用纯化的β2-糖蛋白I通过酶联免疫吸附测定（ELISA）检测了80例SSc患者、20例系统性红斑狼疮（SLE）患者和120名健康对照者的血清样本。80例SSc患者中有8例（10%）存在IgG亚型的β2-GPI/aCL，且β2-GPI/aCL IgG的存在与孤立性肺动脉高压（PH）的存在显著相关。此外，β2-GPI/aCL IgG水平与平均肺动脉压水平显著相关。这些数据表明，IgG亚型的β2-GPI/aCL可能是SSc患者PH严重程度的血清学指标。
