阳光和气温影响大疱性类天疱疮的自身抗体活性及皮肤受累情况。
Sunlight and air temperature affect autoantibody activity and skin involvement of bullous pemphigoid.
作者信息
Kyriakis K S, Panteleos D N, Tosca A D
机构信息
Department of Dermatology and Venereology, West Attica General Hospital, Athens, Greece.
出版信息
Int J Dermatol. 1996 Jul;35(7):498-501. doi: 10.1111/j.1365-4362.1996.tb01666.x.
BACKGROUND AND DESIGN
Sunlight and air temperature are environmental parameters with considerable influence upon autoimmunity. Their impact on idiopathic bullous pemphigoid (BP) was studied 1) in a prospective series of 27 patients with regard to clinical activity and 2) in a retrospective series of 232 cases during a 7-year period with regard to immunoserology.
RESULTS
Skin involvement and the onset of disease showed an immediate and cumulative pattern of response to sunlight and air temperature. Immunoserologic analysis showed a strong correlation of autoantibody expressivity with these two environmental measurements.
CONCLUSIONS
This study verifies previous sporadic clinical and experimental data concerning the influence of environmental factors on BP. Accordingly, preventive measures against exposure to sunlight and high temperature are recommended.
背景与设计
阳光和气温是对自身免疫有重大影响的环境参数。1）对27例患者进行前瞻性研究，观察阳光和气温对特发性大疱性类天疱疮（BP）临床活动的影响；2）对232例患者进行回顾性研究，观察7年间阳光和气温对其免疫血清学的影响。
结果
皮肤受累情况及疾病发作对阳光和气温呈现即时和累积的反应模式。免疫血清学分析表明自身抗体表达与这两个环境指标密切相关。
结论
本研究证实了先前有关环境因素对BP影响的零星临床和实验数据。因此，建议采取预防措施，避免暴露于阳光和高温环境。
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