Pravda M, Vytras K
Department of Analytical Chemistry, University of Pardubice, Czech Republic.
J Pharm Biomed Anal. 1996 May;14(7):765-71. doi: 10.1016/0731-7085(95)01691-0.
Applications of differential pulse anodic stripping voltammetry using a new pen-type renewed hanging mercury electrode have been investigated for trace analysis of lead in pharmaceutical substances and intermediates of their syntheses, such as procaine hydrochloride, 4-aminobenzoic acid, methyl 4-aminobenzoate, 2-(4-chlor-3-aminobenzoyl) benzoic acid, benzyl 2-naphthyl ether, 5-aminoisophthalic acid, 3-aminobenzoic acid, 5-hydroxyisophthalic acid, and N, N'-dibenzylethylenediamine diacetate. Samples were dissolved in 1 M HCI or 1 M NaOH and the electrochemical scan was carried out. No sample mineralization was necessary. The method showed a good linearity up to 50-100 ppm Pb with a detection limit less than 100 ppb. The results agreed well, but were more precise than those obtained by atomic absorption spectrometry using air/acetylene flame atomisation.
使用新型笔型更新悬汞电极的差分脉冲阳极溶出伏安法在药物及其合成中间体（如盐酸普鲁卡因、4-氨基苯甲酸、4-氨基苯甲酸甲酯、2-(4-氯-3-氨基苯甲酰基)苯甲酸、苄基2-萘基醚、5-氨基间苯二甲酸、3-氨基苯甲酸、5-羟基间苯二甲酸和N,N'-二苄基乙二胺二乙酸盐）中铅的痕量分析方面的应用已得到研究。将样品溶解于1 M盐酸或1 M氢氧化钠中并进行电化学扫描。无需样品矿化。该方法在高达50 - 100 ppm铅时显示出良好的线性，检测限小于100 ppb。结果吻合良好，但比使用空气/乙炔火焰原子化的原子吸收光谱法所获得的结果更精确。
