Furihata M, Sonobe H, Iwata J, Ido E, Ohtsuki Y, Asahi Y, Kubonishi I, Miyoshi I
Second Department of Pathology, Kochi Medical School, Japan.
Pathol Int. 1996 May;46(5):376-9. doi: 10.1111/j.1440-1827.1996.tb03624.x.
An autopsy case of a 61 year old male with primary squamous cell carcinoma of the lung with associated marked leukocytosis and hypercalcemia is reported. High levels of serum parathyroid hormone-related peptide (PTHrP) and granulocyte colony stimulating factor (GCSF) were detected. The tumor cells distinctly showed positive cytoplasmic immunoreactions with anti-PTHrP and anti-GCSF antibodies. Marked granulocytosis and thin bony trabeculae lacking osteoblasts were observed in the vertebral bone. Calcium deposits were found in the proximal tubules of the kidneys. Infarcts were seen as a result of fibrin thrombosis of the splenic artery. The tumor was successfully transplanted into nude mice in which the high levels of serum PTHrP and GCSF were reproduced. These results indicate that the tumor simultaneously produced both PTHrP and GCSF causing the paraneoplastic syndromes of hypercalcemia and leukocytosis.
报告了一例61岁男性原发性肺鳞状细胞癌尸检病例，伴有明显的白细胞增多和高钙血症。检测到高水平的血清甲状旁腺激素相关肽（PTHrP）和粒细胞集落刺激因子（GCSF）。肿瘤细胞与抗PTHrP和抗GCSF抗体明显呈现阳性细胞质免疫反应。在椎骨中观察到明显的粒细胞增多和缺乏成骨细胞的细骨小梁。在肾脏近端小管中发现钙沉积。脾动脉纤维蛋白血栓形成导致梗死。该肿瘤成功移植到裸鼠体内，重现了高水平的血清PTHrP和GCSF。这些结果表明，肿瘤同时产生PTHrP和GCSF，导致高钙血症和白细胞增多的副肿瘤综合征。
