Kumagai Takuya, Saito Masaya, Sato Takahiko, Inoue Junichi, Ishikawa Norihisa, Ono Tsuyoshi, Kono Michihiro, Takahashi Naoto
Department of Internal Medicine, Municipal Omori Hospital, Japan.
Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Japan.
Intern Med. 2025 Jun 15;64(12):1933-1940. doi: 10.2169/internalmedicine.3992-24. Epub 2024 Dec 5.
We herein report a case of cutaneous squamous cell carcinoma (SCC) characterized by paraneoplastic hypercalcemia-leukocytosis syndrome. The patient presented with systemic symptoms, including anorexia, a fever, and a tumoral lesion on the upper arm. Laboratory test results revealed hypercalcemia and leukocytosis. A tissue biopsy confirmed SCC, and further investigation revealed elevated parathyroid hormone-related protein (PTHrP) and granulocyte-colony stimulating factor (G-CSF) levels. Immunostaining demonstrated G-CSF production by the tumor cells. Radiation therapy was administered, which improved leukocytosis and decreased G-CSF and PTHrP levels. Through a case report and literature review, we explored the clinical characteristics of tumors that produce G-CSF and PTHrP.
我们在此报告一例以副肿瘤性高钙血症-白细胞增多综合征为特征的皮肤鳞状细胞癌（SCC）。患者出现全身症状，包括厌食、发热以及上臂的肿瘤性病变。实验室检查结果显示高钙血症和白细胞增多。组织活检确诊为SCC，进一步检查发现甲状旁腺激素相关蛋白（PTHrP）和粒细胞集落刺激因子（G-CSF）水平升高。免疫染色显示肿瘤细胞产生G-CSF。给予放射治疗后，白细胞增多得到改善，G-CSF和PTHrP水平降低。通过病例报告和文献综述，我们探讨了产生G-CSF和PTHrP的肿瘤的临床特征。
