Tsutsuml Y, Nakamura M, Machimura T
Department of Pathology, Tokai University School of Medicine, Isehara, Japan.
Pathol Int. 1996 May;46(5):384-8. doi: 10.1111/j.1440-1827.1996.tb03626.x.
Large cell lymphoma with massive necrosis and a phagocytic reaction (malignant histiocytosis-type lymphoma) occurred multifocally in the small and large intestine of a 52 year old male, who had suffered from ulcerative colitis of a pancolonic type for 2 years. After total colectomy and partial jejunectomy, the tumor recurred repeatedly during the subsequent 3-year period. He died of massive intestinal hemorrhage with mild regional lymph nodal involvement. Surface marker studies disclosed CD4/CD8-double negative and CD30+ T cell features. CD3 was weakly expressed. Epstein-Barr virus infection was not identified. The relationship of this neoplasm with 'enteropathy-associated T cell lymphoma' and intestinal Ki-1 lymphoma is discussed.
一名52岁男性，患有全结肠型溃疡性结肠炎2年，其小肠和大肠多处发生伴有大量坏死及吞噬反应的大细胞淋巴瘤（恶性组织细胞增多症样淋巴瘤）。全结肠切除及部分空肠切除术后，肿瘤在随后3年中反复复发。患者死于严重肠出血，伴有轻度区域淋巴结受累。表面标志物研究显示具有CD4/CD8双阴性及CD30+ T细胞特征。CD3表达较弱。未发现爱泼斯坦-巴尔病毒感染。本文讨论了该肿瘤与“肠病相关T细胞淋巴瘤”及肠道Ki-1淋巴瘤的关系。
