复发性鼻乳头状瘤中人乳头瘤病毒DNA的高流行率。
A high prevalence of human papillomavirus DNA in recurrent nasal papillomas.
作者信息
Ogura H, Fukushima K, Watanabe S
机构信息
Department of Molecular Genetics, Okayama University Medical School, Japan.
出版信息
J Med Microbiol. 1996 Sep;45(3):162-6. doi: 10.1099/00222615-45-3-162.
The prevalence of human papillomavirus (HPV) DNA in nasal papillomas was examined by polymerase chain reaction (PCR) and Southern blot hybridisation. HPV 6 DNA in one case, HPV 57 DNA in one case and HPV 16 DNA in three cases were detected amongst 12 cases of nasal papillomas that comprised three cases of fungiform exophytic papillomas and nine cases of inverted papillomas. Five cases (two exophytic and three inverted papillomas) were recurrent and four (80.0%) of these were HPV DNA-positive. The remaining seven cases were non-recurrent and only one (14.3%) was HPV DNA-positive. This difference in HPV DNA detection rates between recurrent and non-recurrent nasal papillomas was statistically significant.
采用聚合酶链反应（PCR）和Southern印迹杂交法检测鼻乳头状瘤中人乳头瘤病毒（HPV）DNA的流行情况。在12例鼻乳头状瘤（包括3例蕈状外生性乳头状瘤和9例内翻性乳头状瘤）中，检测到1例HPV 6 DNA、1例HPV 57 DNA和3例HPV 16 DNA。5例（2例外生性和3例内翻性乳头状瘤）复发，其中4例（80.0%）HPV DNA阳性。其余7例未复发，仅1例（14.3%）HPV DNA阳性。复发性和非复发性鼻乳头状瘤之间HPV DNA检测率的这种差异具有统计学意义。
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