Gajendragadkar S V, Clarke W E
J Int Med Res. 1977;5(4):233-5. doi: 10.1177/030006057700500403.
In a non-blind randomized comparison of sotalol hydrochloride and methyldopa in essential hypertension, the two drugs were equivocal in effect in reaching a preset hypotensive aim, in the maximum decreases from the baseline and in the mean reductions per week from the baseline. Milligram for milligram, sotalol was about twice as potent as methyldopa. No volunteered side-effects were noted for methyldopa; 3/19 for sotalol.
在一项盐酸索他洛尔与甲基多巴治疗原发性高血压的非盲随机对照试验中，两种药物在达到预设降压目标、相对于基线的最大降幅以及每周相对于基线的平均降幅方面效果相当。按毫克计算，索他洛尔的效力约为甲基多巴的两倍。未观察到甲基多巴有自发的副作用；索他洛尔组有3/19的患者出现副作用。
