Kavanaugh A
Department of Internal Medicine, University of Texas, Southwestern Medical School at Dallas 75235-8577, USA.
Clin Immunol Immunopathol. 1996 Sep;80(3 Pt 2):S15-22. doi: 10.1006/clin.1996.0137.
The past decade has witnessed dramatic progress in our understanding of adhesion receptors. These cell-surface molecules serve a critical role in physiologic inflammatory and immunologic responses as well as in various disease states. The expectation that adhesion receptors might serve as useful therapeutic targets for allergic and autoimmune disease has accompanied progress in the field. Significant strides have been made toward this goal, particularly in animal models of human disease.
在过去十年中，我们对黏附受体的理解取得了巨大进展。这些细胞表面分子在生理炎症和免疫反应以及各种疾病状态中发挥着关键作用。随着该领域的进展，人们期望黏附受体可能成为过敏性和自身免疫性疾病的有用治疗靶点。朝着这一目标已经取得了重大进展，特别是在人类疾病的动物模型中。
