Burke D, Fanker S
Department of Aged Care, St George Hospital, Kogarah, New South Wales, Australia.
Aust N Z J Psychiatry. 1996 Apr;30(2):295-8. doi: 10.3109/00048679609076109.
To report three new cases of the fluoxetine-induced syndrome of inappropriate secretion of antidiuretic hormone (SIADH).
All three cases occurred in elderly psychiatric inpatients treated for depression with standard doses of fluoxetine within one month of starting the medication. All three patients were clinically symptomatic of SIADH.
In all three patients the medication was ceased and fluid restriction commenced. One patient required intravenous saline.
All three patients recovered fully within three weeks. None were rechallenged.
The symptoms of hyponatraemia due to fluoxetine-induced SIADH may be difficult to distinguish from the symptoms of depression, unless appropriate laboratory investigations are made.
报告3例由氟西汀引起的抗利尿激素分泌不当综合征（SIADH）的新病例。
3例均发生在老年精神科住院患者中，这些患者在开始服用标准剂量氟西汀治疗抑郁症后1个月内出现该综合征。3例患者均有SIADH的临床症状。
3例患者均停用药物并开始限制液体摄入。1例患者需要静脉输注生理盐水。
3例患者均在3周内完全康复。均未再次接受该药物治疗。
除非进行适当的实验室检查，否则氟西汀引起的SIADH导致的低钠血症症状可能难以与抑郁症症状相区分。
