Málly J, Baranyi M, Vizi E S
St. George Hospital, Székesfehérvar, Hungary.
J Neural Transm (Vienna). 1996;103(5):555-60. doi: 10.1007/BF01273153.
The concentrations of amino acids in the cerebrospinal fluid (CSF) (n = 20) and serum (n = 20) taken from patients with essential tremor were measured by HPLC and compared with those of controls (n = 10). Reduced concentrations of some amino acids (asparagine, glutamine, glycine, threonine, isoleucine, leucine) were observed in serum taken from patients with tremor. Significant increases were detected in the concentrations of glutamate (p < 0.001) and aspartate (p < 0.01). The general tendency of the changes in CSF and serum was similar; although the highest differences were observed in amino acid concentrations in the serum of patients with essential tremor. Opposite shifts of some amino acids were detected, in the concentrations of aspartate, serine, tyrosine, leucine, and isoleucine, which may indicate the independence of the changes in the serum from those in the CSF. This study raises the possibility that a genetically determined metabolic disorder is involved in the etiology of essential tremor that appears peripherally and, partly, centrally. The slight increase in the concentration of glutamate together with the reduced levels of GABA, glycine, and serine in CSF may form the neurochemical basis of the central oscillation observed in essential tremor.
采用高效液相色谱法（HPLC）测定了20例特发性震颤患者脑脊液（CSF）（n = 20）和血清（n = 20）中的氨基酸浓度，并与10例对照者进行比较。在震颤患者的血清中观察到某些氨基酸（天冬酰胺、谷氨酰胺、甘氨酸、苏氨酸、异亮氨酸、亮氨酸）浓度降低。谷氨酸（p < 0.001）和天冬氨酸（p < 0.01）浓度显著升高。脑脊液和血清中变化的总体趋势相似；尽管在特发性震颤患者血清中的氨基酸浓度差异最为明显。检测到天冬氨酸、丝氨酸、酪氨酸、亮氨酸和异亮氨酸浓度存在相反变化，这可能表明血清中的变化与脑脊液中的变化相互独立。本研究提出了一种可能性，即基因决定的代谢紊乱参与了特发性震颤的病因，该疾病部分出现在外周，部分出现在中枢。脑脊液中谷氨酸浓度略有升高，同时γ-氨基丁酸、甘氨酸和丝氨酸水平降低，可能构成特发性震颤中观察到的中枢振荡的神经化学基础。
