Martinez M, Frank A, Diez-Tejedor E, Hernanz A
Department of Biochemistry, Hospital La Paz, Madrid, Spain.
J Neural Transm Park Dis Dement Sect. 1993;6(1):1-9. doi: 10.1007/BF02252617.
Cerebrospinal fluid (CSF) and serum levels of 22 amino acids were studied in 13 patients with dementia of the Alzheimer type (DAT), 13 patients with vascular dementia (VD) and 15 age-matched controls. We found significantly reduced levels of glutamate in CSF samples from DAT patients compared to VD and control subjects, but CSF levels of aspartate were found to be significantly elevated in the two groups of dementia studied. Moreover, CSF concentrations of tyrosine, leucine and phenylalanine were significantly increased in VD patients in comparison with those in DAT patients and control subjects. Our results showed a wide increase in CSF/serum amino acid ratios in DAT and VD groups compared to controls. However, no differences were found in CSF/serum ratios between dementia groups. These changes show evidence for a possible disorder of amino acid metabolism with different patterns in these two dementia types.
对13例阿尔茨海默型痴呆（DAT）患者、13例血管性痴呆（VD）患者和15例年龄匹配的对照者的脑脊液（CSF）和血清中的22种氨基酸水平进行了研究。我们发现，与VD患者和对照者相比，DAT患者CSF样本中的谷氨酸水平显著降低，但在所研究的两组痴呆患者中，天冬氨酸的CSF水平显著升高。此外，与DAT患者和对照者相比，VD患者CSF中的酪氨酸、亮氨酸和苯丙氨酸浓度显著增加。我们的结果显示，与对照组相比，DAT组和VD组的CSF/血清氨基酸比值大幅升高。然而，痴呆组之间的CSF/血清比值未发现差异。这些变化表明这两种痴呆类型可能存在氨基酸代谢紊乱且模式不同。
