Inoue I, Taniuchi I, Kitamura D, Jenkins N A, Gilbert D J, Copeland N G, Watanabe T
Department of Molecular Immunology, Kyushu University 3-1-1, Higashi-ku, Fukuoka, 812, Japan.
Genomics. 1996 Aug 15;36(1):178-81. doi: 10.1006/geno.1996.0441.
We report here the molecular cloning of a mouse histamine H1 receptor gene. The protein deduced from the nucleotide sequence is composed of 488 amino acid residues with characteristic properties of GTP binding protein-coupled receptors. Our results suggest that the mouse histamine H1 receptor gene is a single locus, and no related sequences were detected. Interspecific backcross analysis indicated that the mouse histamine H1 receptor gene (Hrh1) is located in the central region of mouse Chromosome 6 linked to microphthalmia (Mitfmi), ras-related fibrosarcoma oncogene 1 (Raf1), and ret proto-oncogene (Ret) in a region of homology with human chromosome 3p.
我们在此报告小鼠组胺H1受体基因的分子克隆。从核苷酸序列推导的蛋白质由488个氨基酸残基组成，具有GTP结合蛋白偶联受体的特征特性。我们的结果表明，小鼠组胺H1受体基因是一个单一位点，未检测到相关序列。种间回交分析表明，小鼠组胺H1受体基因（Hrh1）位于小鼠6号染色体的中央区域，与小眼症（Mitfmi）、ras相关纤维肉瘤癌基因1（Raf1）和原癌基因Ret相连，位于与人类3号染色体p区域同源的区域。
