雪旺氏细胞中的一种新的钠通道α亚基基因（Scn9a）定位于小鼠2号染色体的Scn1a、Scn2a、Scn3a基因簇。

A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.

作者信息

Beckers M C, Ernst E, Belcher S, Howe J, Levenson R, Gros P

机构信息

Department of Biochemistry, McGill University, Montreal, H3G 1Y6, Canada.

出版信息

Genomics. 1996 Aug 15;36(1):202-5. doi: 10.1006/geno.1996.0447.

DOI:10.1006/geno.1996.0447

PMID:8812438

Abstract

We have used a total of 27 AXB/BXA recombinant inbred mouse strains to determine the chromosomal location of a newly identified gene encoding an alpha-subunit isoform of the sodium channel from Schwann cells, Scn9a. Linkage analysis established that Scn9a mapped to the proximal segment of mouse chromosome 2. The segregation of restriction fragment length polymorphisms in 145 progeny from a Mus spretus x C57BL/6J backcross indicates that Scn9a is very tightly linked to Scn1a (gene encoding the type I sodium channel alpha-subunit of the brain) and forms part of a cluster of four Scna genes located on mouse chromosome 2.

摘要

我们总共使用了27个AXB/BXA重组近交系小鼠品系来确定一个新鉴定的基因的染色体定位，该基因编码施万细胞钠通道的α亚基异构体Scn9a。连锁分析确定Scn9a定位于小鼠2号染色体的近端区域。小家鼠与C57BL/6J回交产生的145个后代中限制性片段长度多态性的分离表明，Scn9a与Scn1a（编码脑I型钠通道α亚基的基因）紧密连锁，并且是位于小鼠2号染色体上的四个Scna基因簇的一部分。