人类假常染色体GM - CSF受体α亚基基因在小鼠中是常染色体基因。

The human pseudoautosomal GM-CSF receptor alpha subunit gene is autosomal in mouse.

作者信息

Disteche C M, Brannan C I, Larsen A, Adler D A, Schorderet D F, Gearing D, Copeland N G, Jenkins N A, Park L S

机构信息

Department of Pathology, University of Washington, Seattle 98195.

出版信息

Nat Genet. 1992 Aug;1(5):333-6. doi: 10.1038/ng0892-333.

DOI:10.1038/ng0892-333

PMID:1363815

Abstract

The gene encoding the granulocyte macrophage colony stimulating factor receptor alpha subunit (CSF2RA) has previously been mapped to the pseudoautosomal region of the human sex chromosomes. In contrast, we report that the murine locus, Csf2ra, maps to an autosome in the laboratory mouse. By in situ hybridization and genetic mapping, Csf2ra maps at telomeric band D2 of mouse chromosome 19. This first instance of a pseudoautosomal locus in human being autosomal in mouse, indicates incomplete conservation between the human and mouse X chromosomes and suggests that the genetic content of the pseudoautosomal region may differ between species of eutherian mammals due to chromosomal rearrangements.

摘要

编码粒细胞巨噬细胞集落刺激因子受体α亚基（CSF2RA）的基因先前已被定位到人类性染色体的假常染色体区域。相比之下，我们报告小鼠基因座Csf2ra在实验室小鼠中定位到一条常染色体上。通过原位杂交和遗传定位，Csf2ra定位于小鼠19号染色体的端粒带D2处。人类假常染色体基因座在小鼠中为常染色体这一首次发现，表明人类和小鼠X染色体之间的保守性不完全，并且提示由于染色体重排，真兽亚纲哺乳动物不同物种之间假常染色体区域的遗传内容可能存在差异。