Leijon M
Department of Biophysics, Stockholm University, Stockholm, S-106 91, Sweden.
J Magn Reson B. 1996 Aug;112(2):181-5. doi: 10.1006/jmrb.1996.0127.
The spin-lock saturation transfer experiment introduced by B. Adams and L. Lerner (J. Magn. Reson. 96, 604-607, 1992) is analyzed in terms of the Bloch equations. It is shown that the T1rho relaxation of the solvent is introduced in the decay of the exchangeable protons under conditions of relatively rapid exchange. An alternative experiment is suggested that randomizes the solvent magnetization with a pulsed field gradient before the observe pulse. This gives a single exponential intensity decay for the exchanging protons at all exchange rates. In addition, efficient water suppression and an even excitation profile are obtained.
B. 亚当斯和L. 勒纳（《磁共振杂志》96卷，604 - 607页，1992年）提出的自旋锁定饱和转移实验依据布洛赫方程进行了分析。结果表明，在相对快速交换的条件下，溶剂的T1ρ弛豫会在可交换质子的衰减过程中引入。有人提出了一种替代实验，即在观测脉冲之前用脉冲场梯度使溶剂磁化随机化。这使得在所有交换速率下，交换质子的强度衰减呈现单一指数形式。此外，还实现了有效的水抑制和均匀的激发分布。
