Rosenbaum W L, Sterling T D, Weinkam J J
Faculty of Applied Sciences, Simon Fraser University, Burnaby, British Columbia, V5A 1S6, Canada.
Regul Toxicol Pharmacol. 1996 Jun;23(3):233-40. doi: 10.1006/rtph.1996.0047.
In response to a request for information on indoor air quality problems, the U.S. Occupational Health and Safety Administration (OSHA) has proposed a rule addressing indoor air quality in general, and especially environmental tobacco smoke (ETS), in indoor work environments. As justification for the proposed rule, OSHA relies on a quantitative risk assessment used to provide estimates of lifetime risk of lung cancer and heart disease associated with workplace exposure to ETS. However, there are a number of concerns regarding the OSHA risk assessment. (i) The form of the underlying mathematical model used in the risk assessment is inappropriate. (ii) OSHA was highly selective in choosing what data values to use in their risk assessment. (iii) Many data values required as input to the OSHA risk assessment model are simply not known at this time. When such values are required, known, but possibly inappropriate, values were substituted. The conclusions arrived at by OSHA on the basis of this risk assessment seem unwarranted.
应关于室内空气质量问题的信息请求，美国职业安全与健康管理局（OSHA）提出了一项规则，该规则总体上涉及室内空气质量，尤其关注室内工作环境中的环境烟草烟雾（ETS）。作为该拟议规则的依据，OSHA依赖于一项定量风险评估，该评估用于提供与工作场所接触ETS相关的肺癌和心脏病终身风险的估计值。然而，对于OSHA的风险评估存在一些担忧。（i）风险评估中使用的基础数学模型形式不合适。（ii）OSHA在选择用于其风险评估的数据值时具有高度选择性。（iii）目前根本不知道OSHA风险评估模型所需的许多数据值。当需要这些值时，使用了已知但可能不合适的值进行替代。基于此风险评估，OSHA得出的结论似乎毫无根据。
