5-脂氧合酶抑制剂对大鼠神经生长因子诱导的热痛觉过敏的影响。
Effect of a 5-lipoxygenase inhibitor on nerve growth factor-induced thermal hyperalgesia in the rat.
作者信息
Amann R, Schuligoi R, Lanz I, Peskar B A
机构信息
Department of Experimental and Clinical Pharmacology, University of Graz, Austria.
出版信息
Eur J Pharmacol. 1996 Jun 13;306(1-3):89-91. doi: 10.1016/0014-2999(96)00255-5.
Intraplantar injection of mouse beta (2.5S) nerve growth factor (NGF) caused thermal hyperalgesia and stimulated release of immunoreactive leukotriene B4 from the rat paw skin. Both effects of NGF were prevented by the 5-lipoxygenase inhibitor, (R)-2-[4-quinolin-2-yl-methoxy)phenyl]-2-cyclopentyl acetic acid (BAY X1005). BAY X1005 did not affect bradykinin-induced thermal hyperalgesia. These results suggest the participation of 5-lipoxygenase products of arachidonate in NGF-induced local thermal hyperalgesia.
将小鼠β（2.5S）神经生长因子（NGF）经足底注射到大鼠体内，可引起热痛觉过敏，并刺激大鼠爪部皮肤释放免疫反应性白三烯B4。5-脂氧合酶抑制剂（R）-2-[4-（喹啉-2-基甲氧基）苯基]-2-环戊基乙酸（BAY X1005）可抑制NGF的这两种作用。BAY X1005对缓激肽诱导的热痛觉过敏没有影响。这些结果表明，花生四烯酸的5-脂氧合酶产物参与了NGF诱导的局部热痛觉过敏。
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