Vahlquist C, Larsson M, Ernerudh J, Berlin G, Skogh T, Vahlquist A
Department of Dermatology, University Hospital, Linköping, Sweden.
Arthritis Rheum. 1996 Sep;39(9):1519-23. doi: 10.1002/art.1780390911.
To study the use of combined photopheresis and psoralen-ultraviolet A irradiation (PUVA) in the treatment of psoriatic arthritis.
Eight patients with psoriasis and sero-negative arthritis received photopheresis for 12 weeks, followed by photopheresis plus PUVA for another 12 weeks. Clinical and laboratory examinations were performed every 3 months for up to 1 year after therapy.
Four patients experienced a marked improvement of joint symptoms that lasted for > or = 12 months post-therapy (74% decrease in the Ritchie articular index; P < 0.01). Prior to therapy, these patients had a higher CD4:CD8 ratio than the poor responders. Only minor laboratory changes occurred.
A more extensive trial of photopheresis plus PUVA in psoriatic arthritis is warranted.
研究联合光化学疗法和补骨脂素-紫外线A照射（PUVA）治疗银屑病关节炎的效果。
8例银屑病合并血清阴性关节炎患者接受了12周的光化学疗法，随后再接受12周的光化学疗法加PUVA治疗。治疗后长达1年的时间里，每3个月进行一次临床和实验室检查。
4例患者关节症状明显改善，且在治疗后持续≥12个月（里奇关节指数下降74%；P<0.01）。治疗前，这些患者的CD4:CD8比值高于反应不佳者。仅出现了轻微的实验室变化。
有必要对光化学疗法加PUVA治疗银屑病关节炎进行更广泛的试验。
