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每日家庭血液透析:血液透析与腹膜透析的结合体。

Daily home hemodialysis: a hybrid of hemodialysis and peritoneal dialysis.

作者信息

Twardowski Z J

机构信息

Department of Medicine, University of Missouri, Columbia, MO 65212, USA.

出版信息

Adv Ren Replace Ther. 1996 Apr;3(2):124-32. doi: 10.1016/s1073-4449(96)80052-5.

Abstract

Despite that routine home hemodialysis, performed with thrice weekly frequency, had provided the best clinical results of any dialysis modality, it has been losing competition to center hemodialysis and home peritoneal dialysis. The main reason for this paradox is a lack of suitable equipment for home hemodialysis. Contrary to peritoneal dialysis, which is easy to learn and perform without need for a helper, home hemodialysis is difficult because the kidney machines are not designed for home therapy. Daily hemodialysis provides even better results than routine home hemodialysis. Several studies showed excellent intradialytic and interdialytic tolerance. In spite of these results the method is used only in a few centers. There are two major reasons for this incongruity: time requirement for the patient and the cost for the provider. With more frequent dialysis, more time is spent on machine setup, tear down, and cleaning. If supplies are not reused, the cost of dialysis increases substantially with increased frequency of dialysis. Daily home hemodialysis may become practical with a new machine. Three components seem crucial for this device: a built-in water treatment system; a simple, small, positive pressure, single pass, batch dialysate system; and a reusable extracorporeal circuit, automatically cleaned and disinfected daily. Daily home hemodialysis performed with the new artificial kidney system may be considered as a hybrid of hemodialysis and peritoneal dialysis. High efficiency is taken from hemodialysis; simplicity is taken from peritoneal dialysis.

摘要

尽管每周进行三次的常规家庭血液透析在所有透析方式中临床效果最佳,但它在与中心血液透析和家庭腹膜透析的竞争中逐渐失利。造成这种矛盾现象的主要原因是缺乏适合家庭血液透析的设备。与腹膜透析不同,腹膜透析容易学习且无需他人协助即可进行,而家庭血液透析则很困难,因为肾脏机器并非为家庭治疗而设计。每日血液透析的效果甚至优于常规家庭血液透析。多项研究显示出良好的透析中和透析间期耐受性。尽管有这些结果,但该方法仅在少数几个中心使用。这种不一致有两个主要原因:患者所需的时间以及提供者的成本。透析频率越高,在机器设置、拆卸和清洁上花费的时间就越多。如果耗材不重复使用,随着透析频率的增加,透析成本会大幅上升。使用新机器后,每日家庭血液透析可能会变得切实可行。该设备的三个组件似乎至关重要:内置水处理系统;简单、小型、正压、单程、批量透析液系统;以及可重复使用的体外循环,每天自动清洁和消毒。使用新型人工肾脏系统进行的每日家庭血液透析可被视为血液透析和腹膜透析的结合体。它借鉴了血液透析的高效性和腹膜透析的简易性。

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