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曲美布汀衍生物的合成及其构效关系

Synthesis and structure-activity relationship of trimebutine derivatives.

作者信息

Sai H, Ozaki Y, Hayashi K, Onoda Y, Yamada K

机构信息

Lead Optimization Research Laboratory, Tanabe Seiyaku Co., Ltd., Osaka, Japan.

出版信息

Chem Pharm Bull (Tokyo). 1996 Jun;44(6):1168-73. doi: 10.1248/cpb.44.1168.

DOI:10.1248/cpb.44.1168
PMID:8814947
Abstract

Trimebutine derivatives were synthesized by utilizing alkylation or acylation of isonitriles and nitrile as a key step. The colonic contractile effects of these compounds were examined, and T-1815 was found to have strong colonic propulsive activity.

摘要

通过将异腈和腈的烷基化或酰化作为关键步骤来合成曲美布汀衍生物。对这些化合物的结肠收缩作用进行了研究，发现T-1815具有很强的结肠推进活性。

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