Magnusson M, Eriksson B I, Kälebo P, Sivertsson R
Department of Clinical Physiology, Ostra Hospital, Göteborg, Sweden.
Thromb Haemost. 1996 Feb;75(2):242-5.
Patients under going orthopedic surgery are at high risk of developing deep vein thrombosis. One hundred and thirty-eight consecutive patients undergoing total hip replacement or hip fracture surgery were included in this study. They were surveilled with colour Doppler ultrasound (CDU) and bilateral ascending contrast phlebography. The prevalence of proximal and distal DVT in this study was 5.8% and 20.3% respectively. CDU has a satisfactory sensitivity in patients with symptomatic deep vein thrombosis, especially in the proximal region. These results could not be confirmed in the present study of asymptomatic patients. The sensitivity was 62.5% (95% confidence interval: C.I. 24-91%) and the specificity 99.6% (C.I. 98-100%) for proximal DVT; 53.6% (C.I. 34-73%) and 98% (C.I. 96-99%) respectively for distal thrombi. the overall sensitivity was 58.1% (C.I. 39-75%) and the specificity 98% (C.I. 96-99%). The positive predictive value was 83.3% (C.I. 36-99%) and 75% (C.I. 51-91%) for proximal and distal DVT respectively. The negative predictive value was 98.9% (C.I. 98-100%) and 94.9% (C.I. 92-98%) for proximal and distal DVT respectively. The results of this study showed that even with a highly specialised and experienced investigator the sensitivity of CDU was too low to make it suitable for screening purposes in a high risk surgical population.
接受骨科手术的患者发生深静脉血栓形成的风险很高。本研究纳入了138例连续接受全髋关节置换术或髋部骨折手术的患者。对他们进行了彩色多普勒超声(CDU)和双侧上行静脉造影检查。本研究中近端和远端深静脉血栓形成的患病率分别为5.8%和20.3%。CDU对有症状的深静脉血栓形成患者,尤其是近端区域,具有令人满意的敏感性。在本无症状患者的研究中,这些结果无法得到证实。对于近端深静脉血栓形成,敏感性为62.5%(95%置信区间:C.I. 24 - 91%),特异性为99.6%(C.I. 98 - 100%);对于远端血栓,分别为53.6%(C.I. 34 - 73%)和98%(C.I. 96 - 99%)。总体敏感性为58.1%(C.I. 39 - 75%),特异性为98%(C.I. 96 - 99%)。近端和远端深静脉血栓形成的阳性预测值分别为83.3%(C.I. 36 - 99%)和75%(C.I. 51 - 91%)。近端和远端深静脉血栓形成的阴性预测值分别为98.9%(C.I. 98 - 100%)和94.9%(C.I. 92 - 98%)。本研究结果表明,即使有高度专业化和经验丰富的研究人员,CDU的敏感性也太低,不适合在高风险手术人群中用于筛查目的。